WebPurpose of review: Peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1alpha) has been extensively described as a master regulator of … Web4 okt. 2015 · PGC-1α increases energy metabolism and weight loss. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homeostasis, …
Measuring PGC-1α and its acetylation status in mouse primary …
PGC-1α is thought to be a master integrator of external signals. It is known to be activated by a host of factors, including: Reactive oxygen species and reactive nitrogen species, both formed endogenously in the cell as by-products of metabolism but upregulated during times of cellular … Meer weergeven Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). … Meer weergeven Recently PPARGC1A has been implicated as a potential therapy for Parkinson's disease conferring protective effects on mitochondrial metabolism. Moreover, … Meer weergeven • MB-3 (drug) • PPARGC1B • Transcription coregulator Meer weergeven • Knutti D, Kralli A (2001). "PGC-1, a versatile coactivator". Trends Endocrinol. Metab. 12 (8): 360–5. doi:10.1016/S1043-2760(01)00457-X. PMID 11551810. S2CID 24230985 Meer weergeven PGC-1α is a super strong gene that contains two promoters, and has 4 alternative splicings. PGC-1α is a transcriptional coactivator that regulates the genes … Meer weergeven PPARGC1A has been shown to interact with: • CREB-binding protein • Estrogen-related receptor alpha Meer weergeven • PPARGC1A protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • NURSA C110 Meer weergeven Web10 dec. 2024 · The AMP-activated protein kinase (AMPK) maintains the energy balance in eukaryotic cells and is a central regulator of cellular responses to metabolic stress 4, 5, 6. Activation of AMPK... sub max heart rate
Essential role of the PGC-1α/PPARβ axis in Ucp3 gene induction
WebGiven the established role of PGC1a in browning of white fat tissue (Wu et al., 1999, Kleiner et al., 2012) and in increasing mitochondrial function in muscle (Lin et al., 2002), we aimed to identify upstream regulators of PGC1a and used the transcrip-tional activation of PGC1a as a readout to characterize novel regulators of energy expenditure. WebPCG1α is activated by deacetylation via sirtuins 36 , and one of the top IPA pathways induced by LXRα S196A in CD68 + cells is sirtuin signaling. ... Inhibiting LXRα phosphorylation in... WebThe mechanisms by which PGC-1alpha gene expression is controlled in skeletal muscle remains largely undefined. Thus, we sought to investigate the transcriptional regulation … submaximal exercise testing examples